Frau mit MTHFR Genmutation und Kinderwunsch

The MTHFR Gene Mutation and Its Impact on Fertility

The MTHFR (Methylentetrahydrofolate Reductase) gene mutation is a genetic alteration where the gene encoding an enzyme does not function properly. This can affect the folate metabolism, as in this case, folic acid cannot be converted into bioavailable folate, which is essential for fertility.

Activated folic acid is crucial for:

  1. Ovarian function
  2. Embryo implantation in the uterine lining
  3. Cell growth and embryonic development

Additionally, elevated homocysteine levels in your blood due to the mutation increase the risk of venous thrombosis and other cardiovascular diseases.

Approximately 30-40% of women in Europe have the heterozygous form, while around 9-11% have the homozygous form of the mutation.

Impact on Fertility

For couples planning a pregnancy, the MTHFR gene mutation can play a significant role. Insufficient folic acid processing due to this mutation is associated with an increased risk of miscarriages, prenatal complications, and developmental disorders in the fetus.

Testing for MTHFR Gene Mutation

Testing is performed through a genetic test (via blood sample). An elevated homocysteine level can be an indicator of an MTHFR gene mutation.

Recommendation for Bioavailable Folate Intake

Women with an MTHFR gene mutation cannot convert folic acid into activated folate, essential for DNA synthesis. Adequate supplementation of folate, the bioactive form of folic acid, is crucial. The intake should begin approximately three months before planned conception.

VILAVIT Female Contains the Required Amount of Bioavailable Folate.